The First Patient by Ethan Thompson

Waldemar Haffkine helped create two of the first major bacterial vaccines used in the modern world: one against cholera and one against bubonic plague.

He tested both on himself.

Born into a Jewish family in the Russian Empire, Haffkine was pushed from Odessa by antisemitism, political violence, and blocked opportunity. In Paris, he entered the Pasteur Institute through a side door and turned from microscopic life to epidemic disease. Then he carried his cholera vaccine to India and, during the terrifying plague epidemic in Bombay, built a plague vaccine under extreme pressure.

His work reached millions. His vaccines helped change the future of public health. Yet after the 1902 Malkowal disaster, when nineteen villagers died of tetanus after receiving plague vaccine from a contaminated bottle, Haffkine was blamed, removed, and nearly erased. Later evidence pointed away from him, but exoneration came too late to restore the career that empire, panic, prejudice, and bureaucracy had broken.

The First Patient tells the story of a scientist who fought invisible enemies — cholera, plague, tetanus, and the politics of blame. It follows Haffkine from Odessa’s Jewish world to the laboratories of Paris, from village trials in India to Bombay’s plague wards, from self-experimentation to mass vaccination, and from public triumph to devastating accusation.

This is not only a story about vaccines. It is a story about exile, empire, medical risk, antisemitism, colonial public health, and the fragile line between saving lives and being made disposable by the institutions that depend on you.